RISK FACTORS OF IMMUNOGLOBULIN RESISTANCE IN CHILDREN WITH KAWASAKI DISEASE
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Abstract
Objectives: To analysis of clinical and laboratory parameters predisposing to immunoglobulin resistance in children hospitalised due to Kawasaki disease. Methods: Prospective, descriptive study. 376 patients were diagnosed with Kawasaki disease at Vietnam National Children’s Hospital from June 2019 to June 2021. Results: 11.2% of patients are resistant with IVIG, 36.4% of patients have
coronary artery lesions (CAL). IVIG resistant patients were diagnosed earlier, had higher percentage of white blood cells representing neutrophils, and higher concentrations of C- reactive protein (CRP), serum alanine aminotransferase (SGPT). They also had lower platelet counts, serum albumin, sodium with statistically significant differences between two groups (p<0.05). Diagnosis ≤5 days, fever ≥8.5 days, percentage of white blood cells representing neutrophils ≥69.1% and CRP ≥136.5 mg/l were independentpredictors of IVIG nonresponse. Conclusions: Diagnosis ≤5 days, fever ≥8.5 days, percentage of white blood cells representing neutrophils ≥69.1% and CRP ≥136.5 mg/l in the initial
show high sensitivity andspecificity in identifying IVIG nonresponders among our Kawasaki patients.
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Keywords
Kawasaki disease, intravenous immunoglobulin resistant Kawasaki.
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