RESULT OF CANDIDEMIA TREATMENT IN UNDER 32 WEEK GESTATIONAL AGE PRETERM INFANTS AT THE NATIONAL HOSPITAL OF PEDIATRIC
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Abstract
Aims: Assessing result of candidemia in under 32 week gestational age preterm infants at neonatal care center, the National hospital of pediatric. Methods: Descriptive cross-sectional study, 45 under 32 weeks gestational age preterm infants at Neonatal care center, the National hospital of pediatric from 7/2019 to 6/2021. Results: There were 45 preterm infants whose blood cultures were positive for Candida. Average age was 29 ± 1.9 weeks , average birth weight was 1300 ± 466g. Risk factors associated with colonization included length of the Neonatal Intensive Care Unit stay >7 days 84.4%, using third generation cephalosporins or carbapenem 91.1%, presence of central catheter 71.1%
and low platelet count 75.5%. Candida albicans and Candida parapsilosis were the most commonly isolated Candida species, accounting for over 60 percent of cases, followed by Candida tropicalis, Candida pelliculosa, Candida krusei and Candida guillerrmondii, most Candida species were sensitive to antifungal medicine. The average period of hospitalizationstay was 30 ± 22.7 days, the duration of antifungal treatment was 20.14 ± 10.6 days, the time of negative culture after 8 ± 8.6 days. Mortality rate due to invasive candidiasis is 26.67%. Conclusions: Invasive candidiasis is the primary cause of death in premature infants. Fluconazole and Amphotericin B are still the mainstays in the treatment
of fungal infections, but the resistance has developed and must be treated with new classes of antifungal drugs such as Caspofungin.
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Keywords
Candidemia, under 32 weeks gestational age preterm infants.
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