DỊCH TỄ HỌC LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ NHIỄM CYTOMEGALOVIRUS Ở TRẺ ĐẺ NON CÂN NẶNG THẤP MẮC BỆNH LOẠN SẢN PHẾ QUẢN PHỔI

Abstract

Bronchopulmonary dysplasia is the most common chronic lung disease in pretem, low birth weight infants. CMV infection in preterm infants can be congenital or acquired after birth. CMV infection can attribute to the development of BPD and the severity of the disease. The study was conducted in 15 patients with BPD and CMV infection. The boy to girl ratio was 1.5/1. The mean gestational age was 27.7 ± 1.6 weeks, the mean birth weight was 1026.6 ± 187g. Most of the mothers did not receive anternatal corticosteroid. The reason for CMV testing was prolonged mechanical ventilation (53.3%), not weaning from oxygen (33.3%), apnea (6.7%) and severe pneumonia (6.7%). The mean viral load in blood and in intratracheal tube secretion was 2.94 x 106 ± 7.43 x 106 copies/Ml and 5.71 x 106 ± 1.9 x 107 copies/Ml, respectively. The average duration of respiratory support after treatment was 14.3 ± 11.6 days. 86.7% patients was discharged with full recovery. No patients witnessed adverse side effects of antiviral treatment.