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Published: 2026-06-24
Abstract Views: 21
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DOI: https://doi.org/10.52724/tcnk.v19i2.497
Issue
Vol. 19 No. 2 (2026)
Section
Research

CURRENT STATUS AND FACTORS ASSOCIATED WITH THE SWITCH OVER FROM INTRAVENOUS TO ORAL ANTIBIOTIC THERAPY BEFORE AND AFTER ANTIMICROBIAL STEWARDSHIP PROGRAM INTERVENTIONS AT THE INTERNATIONAL CENTER OF VIETNAM NATIONAL CHILDREN’S HOSPITAL

Tam Duong Thi Thanh1, Huy Do Khac1, Mai Hoang Thi Thanh1, Hang Nguyen Thi1, Nga Nguyen Thi1, Anh Nguyen Viet1
1 Vietnam National Children’s Hospital

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Abstract

Objective: To evaluate the current status and factors associated with intravenous-to-oral antibiotic switch before and after antimicrobial stewardship program interventions at the International Center - Vietnam National Children’s Hospital during 2021-2024.


Methods: A retrospective and prospective cohort study combined with a cross-sectional physician survey was conducted. Outcome measures included antibiotic switch rates, appropriate switch rates, duration of prolonged intravenous antibiotic use, and factors affecting antibiotic switch decisions.


Results: During the retrospective period in 2021, 88.1% of patients were eligible for intravenous-to-oral antibiotic switch; however, no switch was performed. During the prospective period from 2022 to 2024, 94.5% of patients underwent oral antibiotic switch, of which 87.5% were considered appropriate. The mean duration of prolonged intravenous antibiotic use decreased from 2.77 to 0.21 days. Major barriers to antibiotic switch included treatment adherence of patients and caregivers, preference for continued intravenous therapy, and unpredictable clinical progression in pediatric infections.


Conclusion: The rate of intravenous-to-oral antibiotic switch improved markedly following antimicrobial stewardship program interventions. However, the switching process was still influenced by multiple factors related to patients, caregivers, and physicians’ perceptions. These findings provide practical evidence for implementing antibiotic switch activities in pediatric hospitals.

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Keywords

Antibiotics conversion, antimicrobial stewardship, intravenous antibiotics, oral antibiotics, Vietnam National Children Hospital

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