MICROBIOME TRÊN DA BỆNH NHÂN VIÊM DA CƠ ĐỊA
##plugins.themes.vojs.article.main##
Abstract
Atopic dermatitis is a chronic, recurring inflammatory skin disease with the predominant symptom of itching and inflammatory lesions on the skin. This disease has a complex pathogenesis related to many factors ranging from skin barrier abnormalities, genetic and environmental factors. Microbiosome on the skin refers collective genomes or genetic material of all microbes on the skin. Microbiome in atopic dermatitis plays a role in preventing colonization and growth of pathogens on the skin, and also has an impact human immune system. Skin dysbiosis is related to the severity of atopic dermatitis. The advanced concept of modulating the skin microbiome using moisturizers containing non-pathogenic bacteria or probiotic supplements during the first years of life may be a preventative and therapeutic option in treatment high-risk groups, but currently lack of evidence. This article provides information discussing the characteristics, role in pathogenesis and future applications of the skin microbiome in patients with atopic dermatitis.
##plugins.themes.vojs.article.details##
Keywords
Microbiome, atopic dermatitis, viêm da cơ địa
References
[2] Agarwal A, Chen L, Capozza K et al. Trustworthy Patient-Centered Guidelines: Insights From Atopic Dermatitis and a Proposal for the Future. J Allergy Clin Immunol Pract 2022;10(11):2875–2877. https://doi.org/10.1016/j.jaip.2022.06.017
[3] Boguniewicz M, Leung DYM. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol. Rev 2011;242(1):233–246. https://doi.org/10.1111/j.1600-065x.2011.01027.x
[4] Kuo IH, Yoshida T, De Benedetto A et al. The cutaneous innate immune response in patients with atopic dermatitis. J Allergy Clin Immunol 2013;131(2):266–278. https://doi.org/10.1016/j.jaci.2012.12.1563
[5] Czarnowicki T, He H, Krueger JG et al. Atopic dermatitis endotypes and implications for targeted therapeutics. J Allergy Clin Immunol 2019;143(1):1–11. https://doi.org/10.1016/j.jaci.2018.10.032
[6] Kim JE, Kim HS. Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies. J Clin Med 2019;8(4):444. https://doi.org/10.3390/jcm8040444
[7] Belkaid Y, Serge JA. Dialogue between skin microbiota and immunity. Science 2014;346(6212):954-959. https://doi.org/10.1126/science.1260144
[8] Shi B, Bangayan N, Curd E et al. The skin microbiome is different in pediatric versus adult atopic dermatitis. J Allergy Immunol 2016;138(4):1233-1236. https://doi.org/10.1016/j.jaci.2016.04.053
[9] Paller AS, Kong HH, Seed P et al. The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol 2019;143(1):26–35. https://doi.org/10.1016/j.jaci.2018.11.015
[10] Totté JEE, der Feltz WT, Hennekam M et al. Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol 2016;175(4):687–695. https://doi.org/10.1111/bjd.14566
[11] Kong HH, Oh J, Deming C et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 2012;22(5):850-859. https://doi.org/10.1101/gr.131029.111
[12] Findley K, Oh J, Yang J et al. Topographic diversity of fungal and bacterial communities in human skin. Nature 2013;498(7454):367-370. https://doi.org/10.1038/nature12171
[13] Bjerre RD, Bandier J, Skov L et al. The role of the skin microbiome in atopic dermatitis: a systematic review. Br J Dermatol 2017;177(5):1272–1278. https://doi.org/10.1111/bjd.15390
[14] E. A. Kennedy et al., “Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year,” J. Allergy Clin. Immunol., vol. 139, no. 1, pp. 166–172, Jan. 2017, doi: 10.1016/j.jaci.2016.07.029.
[15] Kenndy EA, Connolly J, Hourihane JOB et al. Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy - ScienceDirect. J Allergy Clin Immunol 2017;139(1):166-172. https://doi.org/10.1016/j.jaci.2016.07.029
[16] T. Nakatsuji, Chen TH, Narala S et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med 2017;9(378):eaah4680. https://doi.org/10.1126/scitranslmed.aah4680