INVESTIGATION OF HUMORAL IMMUNE DISORDERS IN CHILDREN WITH SEPSIS IN PEDIATRIC INTENSIVE CARE UNIT IN DA NANG HOSPITAL FOR WOMEN AND CHILDREN
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Tóm tắt
Background: Sepsis has a complex pathophysiology with several diverse and nonspecific mechanisms. Objective: To investigate humoral immune disorders and some related factors in the prognosis of 28-day mortality in children with sepsis. Subjects and methods: A descriptive cross-sectional study of 91children with sepsis treated in Pediatric Intensive Care Unit in Da Nang Hospital for women and children from January 2020 to January 2022. Results: 29 patients had low levels ofi mmunoglobulins, in which the independent decrease of IgG concentrations accounted for the highest rate of 31.1%, the lowest was a decrease of bothIgM + IgA levels(3.5%). There was a statistically signifi cant diff erence between septic shock, multiorgan dysfunction syndrome, white blood cell count, platelet count, albumin and
procalcitonin with IgG and IgM levels, p < 0.05. There was no diff erence in 28-day mortality
between two groups of low and high IgG levels after adjusting for some related factors (p>0.05). Conclusion: There were humoral immune disorders in children with sepsis. However, the levels of immunoglobulinshad no prognostic values for 28-day mortality.
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Từ khóa
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