CLINICAL, PARACLINICAL, AND HISTOPATHOLOGICAL CHARACTER-ISTICS OF IGA NEPHROPATHY CASES AT CHILDREN’S HOSPITAL 2
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Abstract
Objective: To describe epidemiological, clinical, and paraclinical characteristics of pediatric patients with IgA nephropathy at Children's Hospital 2.
Methods: A retrospective descriptive case series on children aged ≤ 16 years who underwent renal biopsy and were diagnosed with IgA nephropathy at Children's Hospital 2 in the period of 2021-2025
Results: The mean age was 10.5 years, with a male-to-female ratio of 2.6/1. Isolated gross hematuria, edema, and hypertension were observed in 40%, 40%, and 20% of patients, respectively; 15% had decreased glomerular filtration rate. Nephrotic-range proteinuria was present in 60% of patients. The most frequent histopathological lesion based on the MEST-C classification was mesangial hypercellularity; neither T2 nor C2 lesions were recorded.
Conclusion: The mean age at diagnosis of IgA nephropathy was 10 years, with a male predominance. 10% of children present with asymptomatic urinary abnormalities. 90% present with clinical manifestations accompanied by urinary abnormalities. Based on the MEST-C classification, mesangial hypercellularity was the predominant finding.
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Keywords
IgA nephropathy, children, renal biopsy
References
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