IMPLEMENTATION OF HOME-BASED ORAL FOOD CHALLENGE IN CHILDREN WITH NON-IGE-MEDIATED COW’S MILK PROTEIN ALLERGY SAFETY AND FEASIBILITY
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Tóm tắt
This study aimed to evaluate the safety, feasibility, and diagnostic value of the slow, mainly home-based oral food challenge (OFC) protocol in children with non-IgE-mediated cow’s milk allergy (CMA). A cross-sectional study was conducted on 51 children, mostly under 2 years old, examined at Children’s Hospital 1 from July 2024 to July 2025. All participants underwent the slow-protocol OFC, starting with 30 mL of cow’s milk at the hospital, followed by gradual dose increases of 30 mL every 2–3 days at home, under remote medical supervision. Results showed that 78.4% of children tolerated cow’s milk again, while 21.6% had a positive OFC response, mainly presenting with mild to moderate gastrointestinal or skin symptoms. No severe adverse events were recorded. Symptoms appeared between day 2 and day 19 after dose escalation began; the median time from OFC initiation to final diagnosis was 28 days (IQR 20–30). The slow-protocol OFC conducted at home proved to be safe, feasible, and diagnostically valuable in pre-screened children, as the majority of those initially suspected of allergy were found to tolerate cow’s milk after a period of elimination.
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Từ khóa
cow’s milk allergy, non-IgE-mediated allergy, oral food challenge, home-based challenge
Tài liệu tham khảo
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