CLINICAL AND LABORATORY FEATURES OF CORONARY ARTERY ANEURYSMS IN KAWASAKI DISEASE

Tóm tắt

Objective: describe clinical and laboratory features of coronary artery aneurysms (CAA) in Kawasaki disease.

Patients and methods: 545 patiens with Kawasaki disease at Cardiovascular Center – Vietnam National Children’s Hospital between January 2019 and June 2022.

Results: Patients were classifed as 4 groups: no involvement, small aneurysm, medium aneurysm, large or giant aneurysm (GAA). The rates of 4 groups were: 44.6%, 19.4%, 18.2%, 7%. The average age at diagnosis of 12.6 months, 49.4% under 12 months, the ratio of male: female approximates 1.5: 1, 11.7% had atypical Kawasaki disease with lowest in no involvement group and highets in GAA group. Day at diagnosis, day of IVIG, total fever duration, IVIG-nonresponsive, the white blood cell count pre-IVIG, CRP pre-IVIG, platelets post-IVIG increased gradually with levels of CAA, but hemoglobin pre-IVIG, albumin decreased with levels of CAA, statistically signifcant differences between four groups (p<0.05).

Conclusions: In the subacute phage, there is a high rate of CAA. It had higher duration of diagnosis, IVIG resistance, white blood cell count, CRP and lower albumin, hemoglobin, age with another groups. The inflammatory response status increases with the level of CAA. There are statistically signifcant differences in some clinical and labotory variables in four groups.