CLINICOPATHOLOGICAL CHARACTERISTICS AND EARLY RESULTS OF SURGICAL TREATMENT FOR PEDIATRIC THYROID CANCER AT NATIONAL HOSPITAL ENDOCRINOLOGY

Nguyen Van Loc, Tran Ngoc Luong, Phan Hoang Hiep

##plugins.themes.vojs.article.main##

Abstract

Thyroid cancer remains a rare malignancy in the pediatric population, comprising 0.7% of all childhood cancers, and the overall incidence of thyroid cancer is increasing. Objective: To evaluate the clinical, paraclinical, and early results of surgical treatment for pediatric thyroid cancer. Subjects: including 85 children who operated at national hospital endocrinology from January 2018 to
December 2020. Research method: A retrospective study. Results: Mean age of patients were 15.02±3.098 (range 3-18 years), the rate female was 82.4%, the
most cases were not symptoms (83.5%), 56.5% of patients was larger than 2cm, nineteen patients have extracapsular nodules, 2 patients were suspended lung metastasis. 85.9% of patients operated on thyroidectomy and/or neck dissection. The proportion of centre neck lymp node metastasis and lateral neck metastasis were 55.3% and 36.6%. Univariate logistic regression demonstrated that: centre neck lymp node metastasis and lateral neck metastasis were associated with tumor size ≥ 2cm, extracapsular, lymph node suspends US. The most complications were temporary hypoparathyroidism (17.6%), temporary recurrent laryngeal nerve injury (10.6%), four patients were chyle fi stular (one
was reoperated).

##plugins.themes.vojs.article.details##

References

1. Bucsky P, Parlowsky T. Epidemiology and therapy of thyroid cancer in childhood
and adolescence. Experimental and clinical endocrinology & diabetes: offi cial journal,
German Society of Endocrinology [and] German Diabetes Association. 1997. 105 Suppl 4:70-73.
doi:10.1055/s-0029-1211938.
2. Chen AY, Jemal A, Ward EM. Increasing incidence of diff erentiated thyroid cancer in the
United States, 1988-2005. Cancer. 2009. 115(16):3801-3807 % U http://doi.wiley.com/3810.1002/cncr.24416.
3. Bucsky P, Parlowsky T. Epidemiology and therapy of thyroid cancer in childhood
and adolescence. Experimental and Clinical Endocrinology & Diabetes. 2009. 105(S 04): 70-
73 % U http://www.thieme-connect.de/DOI/ DOI:10.1055/s-0029-1211938.
4. Francis GL, Waguespack SG, Bauer AJ, et al. Management Guidelines for Children with
Thyroid Nodules and Diff erentiated Thyroid Cancer: The American Thyroid Association
Guidelines Task Force on Pediatric Thyroid Cancer. Thyroid : offi cial journal of the American
Thyroid Association. 2015. 25(7) :716-759 %U https://www.liebertpub.com/doi/710.1089/
thy.2014.0460.
5. Francis GL, Waguespack SG, Bauer AJ, et al. Management Guidelines for Children with
Thyroid Nodules and Diff erentiated Thyroid Cancer. Thyroid : offi cial journal of the American
Thyroid Association. Jul 2015. 25(7): 71 6-759. doi:10.1089/thy.2014.0460.
6. Hogan AR, Zhuge Y, Perez EA, Koniaris LG, Lew JI, Sola JE. Pediatric thyroid carcinoma:
incidence and outcomes in 1753 patients. The Journal of surgical resear ch. Sep 2009. 156(1):167-172. doi:10.1016/j.jss. 2009.03.098.
7. Al-Qurayshi Z, Adam Hauch M, Srivastav S, Aslam R, Friedlander P. A National Perspective of
the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer. JAMA otolaryngol ogy head & neck surgery. 2016.
8. Burke JF, Sippel RS, Chen H. Evolution of pediatric thyroid surgery at a tertiary medical
center. Journal of Surgical Research. 2012. 177(2):268-274 %U https://linkinghub.elsevier.
com/retrieve/pii/S0022480412006075.
9. Scholz S, Smith JR, Chaignaud B, Shamberger RC, Huang SA. Thyroid surgery at Children’s
Hospital Boston: a 35- year single-institution experience. Journal of pediatric surgery. 2011.
46(3): 437-442 %U https://linkinghub.elsevier.com/retrieve/pii/S0022346810007888.