Clinical and laboratory features of bacterial meningitis in newborn
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Abstract
Objectives: To describe clinical and laboratory features of bacterial meningitis in neưborn. Patients and methods: 133 newborns diagnosed with bacterial meningitis at Neonatal Departement - National Hopital of Pediactrics between July 2019 and June 2020. Results: In total 133 newborns, there were 32 babies diagnosed with late-onset barterial meningitis. Preterms babies had more early-onset
barterial meningitis than full-term babies. Clinical features included: change in temperature (63.1%), jaundice (53.3%), which were common in full-term newborn; respiratory distress (60.2%), arrhythmia (60.2%), poor feeding (95.5%), feeding refusal (61.7%) lethargy (42.8%) happening in premature infants. The CRP value increased with a median of 31.4 (81.6) mg/l. Cerebrospinal fluid parameters with the median of 78 leukocytes/mm3 , the median of protein concentration of 1.3 g/L, the median of glucose level of 2.5 mmol/L. With cerebrospinal fluid culture, we identified 6 pathogens caused neoantal barterial meningitis. Conclusions: Clinical symptoms of meningitis in neonatal were not specific. Lumbar puncture had important role to diagnose bacterial meningitis in neonatal. The results of cerebrospinal fluid culture play an important role in the diagnosis but the positive rate is still low.
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Keywords
neonatal meningitis, neonatal onset sepsis, newborn.
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