ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA NHIỄM CYTOMEGALOVIRUS BẨM SINH TẠI TRUNG TÂM SƠ SINH BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objectives: To document the clinical manifestations and laboratory findingsof congenital cytomegalovirus infection in the Neonatology Center of National Children’s Hospital. Method: Research on 30 newborns were diagnosed with congenital CMV infection admitted to the Neonatal Center, National Children’s Hospital from January 2018 to April 2021. Children are evaluated clinically and subclinically for diseases in the neonatal period. Results: Children with congenital CMV infection have the following characteristics: 50.0% of premature; average birth weight was 2270±540gr; 63.3% SGA. Common clinical symptoms at presentation were jaundice, hepatomegaly, and splenomegaly seen in 43.3% of children. Thrombocytopenia, increased direct bilirubin and increased transaminases were present in 63.3%; 56.7%; 52.4% respectively. 18/28 (64.3%) children with congenital CMV infection had at least one neuroimaging abnormality. 8/15 (53.3%) children had hearing loss or impairment at the first AABR screening and 14.3% had eye abnormalities. The rate of positive CMV-IgM was 88.5%. Conclusions: Congenital CMV infection remains a disease that impactspreterm birth, low birth weight and other severe sequelae. Clinical manifestations are diverse and often involve systemic effects on multiple organs.