CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH HIGH-RISK HEPATOBLASTOMA AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL
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Abstract
Hepatoblastoma is a common malignant liver tumor in children, SIOPEL 3 high risk and SIOPEL 4 regimens improve treatment outcomes for children with high risk hepatoblastoma.
Objective: Describe the clinical and paraclinical features and initial treatment outcomes in children with high-risk hepatoblastoma.
Subjects and methods: 41 children under 15 years old were diagnosed with hepatoblastoma (2020-2024), treated according to high-risk regimen at the Oncology Center - Vietnam National Children’s Hospital. Method: case series, retrospective study.
Result: The median age was 12 months (min: 2 months old, max: 14 years old). Male/female ratio: 1.2/1. Common clinical symptoms were abdominal distension, palpable tumor, or incidental detection by abdominal ultrasound. About 90% of cases presented with anemia, 68.3% thrombocytosis. 51.2% had solitary tumors and 63.4% had right liver tumors. The rate of pulmonary metastasis was 31.7%. There were 4 cases of liver transplantation and 6 cases of embolization. The overall survival and event-free survival rates 3-year were 78,33% và 72,24%, respectively.
Conclusion: The treatment results of high-risk hepatoblastoma have improved signifcantly in recent years.
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