SỰ PHÁT TRIỂN THỂ CHẤT Ở TRẺ SUY GIÁP BẨM SINH SAU ĐIỀU TRỊ TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: To evaluate the physical development of children with congenital hypothyroidism after treatment Vietnam National Children’s Hospital.

Subjects and Methods: A prospective and retrospective descriptive study was conducted on 53 children with congenital hypothyroidism who were diagnised, treated, and followed up at the Endocrinology Outpatient Clicnic of Vietnam National Children’s Hospital between January 2022 and August 2025, with a minimum treatment duration of 12 months.

Result: Between January 2022 and August 2025, 53 patients with congenital hypothyroidism were diagnosed and managed at the Endocrinology Outpatient Clinic of Vietnam National Children’s Hospital. Of these, 81.1% were diagnosed before 3 months of age, 11.3% between 3-12 months, and 7.5% after 12 months. After one year of treatment, children diagnosed before 3 months showed the greatest catch-up growth, with a mean weight gain of 6.0 kg and a mean height increase of 23.5 cm, whereas later-diagnosed groups demonstrated lower gains, 3.0-3.5 kg in weight; 14.25 cm and 12.25 cm in height for those diagnosed at 3-12 months and >12 months, respectively.

Conclusion: Delayed diagnosis and treatment of congenital hypothyroidism are associated with impaired physical development in children. Following initiation of levothyroxine therapy, marked catch-up growth in both weight and height typically occurs within the frst year, with the most pronounced acceleration observed during the initial three months of treatment. Importantly, children who receive a diagnosis and commence therapy before three months of age achieve more favorable growth trajectories than those with later diagnosis.