CLINICOPATHOLOGICAL CHARACTERISTICS OF CHILDREN IGA NEPHROPATHY IN VIETNAM NATIONAL CHILDREN’S HOSPITAL
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Abstract
Objective: To describe the clinical, laboratory, and histopathological features of IgA nephropathy in children at the National Children’s Hospital, and to assess their correlations.
Methods: A case series was diagnosised IgA neprhopathy with retrospective and prospective longitudinal follow-up was conducted in the Department of Nephrology and Dialysis, Viet Nam National Children’s Hospital, from January 2023 to May 2025.
Results: A total of 64 patients met inclusion criteria. The mean age was 11.4 years (range 4.9–16.6), with 45 males (70.3%). Gross hematuria, edema, and hypertension were present in 70.3%, 57.1%, and 10.9% of patients at presentation, respectively. Nephrotic syndrome was observed in 60.9% and reduced estimated glomerular filtration rate (eGFR) at diagnosis in 23.4%. The most frequent histopathological lesion by the 2016 Oxford classification was segmental glomerulosclerosis. No T2 lesions were observed. Hematuria severity, T1 and C2 lesions were associated with reduced eGFR.
Conclusion: In children, the mean age at onset of IgA nephropathy was 11 years, predominantly in males. Chronic histopathological lesions were less common in pediatric patients. Severe hematuria, tubular atrophy/interstitial fibrosis, and cellular crescents were associated with reduced eGFR.
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Keywords
IgA nephropathy in children, pathological, Oxford classification 2016
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