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Published: 2025-08-22
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Issue
Vol. 18 No. 2 (2025)
Section
Research

DETECT CHROMOSOMAL ALTERATIONS IN PATIENTS WITH NEUROBLASTOMA USING ARRAY COMPARATIVE GENOMICS HYBRIDIZATION TECHNIQUE

Thanh Tam Nguyen1, Thi Phuong Mai Nguyen1, Thi Mai Huong Nguyen1, Thuy Trang Nguyen1, Xuan Huy Nguyen1, Thuy Lan An1, Diem Ngoc Ngo1, Thi Lien Nhi Tran1, Hoai Anh Nguyen1, Dinh Cong Le1, Thi Kim Ngoc Le1, Ngoc Thach Hoang1, Hong Diep Pho1, Tho Anh Nguyen2, Manh Hoan Vu1, Ngoc Lan Bui1, Viet Tung Cao1, Minh Dien Tran1
1 Vietnam National Children’s Hospital
2 ietnam National Children’s Hospital

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Abstract

Neuroblastoma is one of the most common malignancies in children, accounting for about 8% of childhood cancers, ranking 4th after acute leukemia, brain tumors and lymphomas.


Samples: 2 patients with mediastinal tumor detected and diagnosed with neuroblastoma, without MYCN amplication being treated at Center of Children’s Cancer, National Children’s Hospital.


Methods: We used aCGH comparative genomic hybridization technique with 60K resolution.


Results: Two patients had detected genetic mutations of SCA and SCA combined with NCA.


Conclusion: Applying aCGH technique with resolution from 60K can detect genetic changes in neuroblastoma patients. This is the basis for more effective prognosis and treatment of neuroblastoma in the future.

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Keywords

Neuroblastoma, aCGH, NCA, SCA

References

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2. Ambros IM, Brunner B, Aigner G et al. A Multilocus Technique for Risk Evaluation of Patients with Neuroblastoma. Clin Cancer Res 2011;17(4):792-804. https://doi.org/10.1158/1078-0432.ccr-10-0830
3. Attiyeh EF, London WB, Mossé YP et al. Chromosome 1p and 11q-dels and outcome in NB. N Engl J Med. 2005; 353:2243–53.https://doi.org/10.1056/nejmoa052399
4. Barr EK, Applebaum MA. Genetic Predisposition to Neuroblastoma. Children (Basel) 2018;5(9):119. https://doi.org/10.3390/children5090119