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Published: 2025-08-22
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Issue
Vol. 18 No. 2 (2025)
Section
Research

EVALUATION OF HUMORAL IMMUNITY IN CHILDREN WITH RECURRENT RESPIRATOTY TRACT INFECTIONS AT THE PEDIATRICS DEPARTMENT OF VINMEC TIMECITY INTERNATIONAL GERENAL HOSPITAL

Thị Minh Hương Le1, Khac Tiep Pham1, Thi Thao Do1, Thi Kim Oanh Bui1, Lan Huong Pham1
1 Vinmec Times City International Hospital

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Abstract

Evaluation of humoral immunity in children with recurrent respiratoty tract infections focuses on the role of immunoglobulin antibadies, helpng to determine the child’s immune responese capability while simultaneously excluding underlying immunodeciency disorders.


Method: A cross-sectional descriptive study of 207 cases, aged 6 months to 8 years, diagnosed with recurrent respiratory tract infections. The study indicators included medical history, respiratory inammation inđẽ according to the ICD 10, frequency of infections, and measurement of antibody levels (IgA, IgG, IgM, IgE). The antibody levels were compared with reference values by age group.


Results: The average age of the study patients was 2.48 ± 1.46 years, with the majority being children under 3 years old (accounting for 69.6%). The percentage of boys is 63,6%. The most frequently encounted conditions, in order, are acute pharyngitis (100%), bronchitis (66,7%), otitis media (53,6%) and pneumonia (45,9%). IgA concentration was reduced in 7,7% children in the study. The younger the child, the higher rate of IgA reduction (14.5% in the 6-12 month age group, 7.1% in the 2-3 year age group). The frequency of lower respiratory tract infections was signicantly higher in the 2-3 year age group with decreased IgA levels (p=0.007). 2.4% of children had decreased IgG levels, mainly concentrated in the under 1 year old group, accounting for 7%. In addition, 23.1% of children had elevated IgE levels regardless of age.


Conclusion: Recurrent respiratory tract infections are more common in young children under 3 years old. 7.7% of children with recurrent respiratory tract infections had reduced IgA and 2.4% had decreased IgG compared to the reference values by age. There is a relationship between decreased IgA levels and the frequency of lower respiratory tract infections in the 2-3 years old group.


 

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Keywords

Recurrent respiratory tract infections, humoral immunity, children

References

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