VAI TRÒ CỦA PROBIOTICS TRONG HEN PHẾ QUẢN Ở TRẺ EM
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Abstract
Asthma is the most common chronic respiratory disease in children, with the involvement of many cells and components that increase airway responsiveness, causing obstruction, limiting exhaled airflow, leading to recurrent episodes of wheezing, breathlessness , chest tightness and coughing. The main available treatments currently for asthma include accurate assessment of asthma severity and the use of β2 - adrenergic agonists, which are bronchodilators for acute reactions, and anti-inflammatory drugs such as inhaled corticosteroids for conservative treatment to prevent.
Probiotics are living microorganisms that are found in the human gut and many other locations such as lung, skin, genitourinary system... The intestinal microbiota and the microbiota in these organs are closely linked through the gut-brain axis, gut-lung axis, gut-skin axis... This microbiota has a competitive effect, creating a biofilm barrier to prevent the invasion of harmful foreign microorganisms, and at the same time activating macrophages and NK cells produce Cytokine and Chemokine, which are important signaling molecules in the immune system, playing a key role in destroying viruses as well as regulating the immune system. In children, the microbiota is not yet completed and can be affected by drug use, especially antibiotics. Therefore, supplementing probiotics may rebalance immune response, repair dysbiosis and reduce respiratory inflammation, thereby helping to prevent recurrence of bronchial asthma exacerbations and wheezing.
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Keywords
hen phế quản, probiotic, trẻ em, asthma, probiotics, children
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