NGHIÊN CỨU ĐẶC ĐIỂM DỊCH TỄ HỌC, LÂM SÀNG VÀ CÁC YẾU TỐ TIÊN LƯỢNG NẶNG Ở BỆNH NHI SỐT XUẤT HUYẾT DENGUE TẠI BỆNH VIỆN SẢN - NHI TỈNH QUẢNG NGÃI

Abstract

Introduction: Dengue hemorrhagic fever (DHF) is an acute infectious disease caused by the dengue virus. Dengue viruses is transmitted by the mosquito Aedes aegypti. According to statistics, by 2020, it is estimated about 3.6 billion people in more than 100 countries living in areas with endemic dengue virus, 100 million symptomatic cases of dengue every year, 2%-5% of which are severe. Dengue hemorrhagic fever is a disease with various clinical manifestations, rapidly progressing from mild to severe, manifested by plasma leakage and coagulation disorders, lead to cardiovascular collapse, shock (from 1-5% ). If not diagnosed early and treated immediately can lead to prolonged shock, multi-organ failure and lifethreatening. So far, there is no specifc treatment drug and the vaccine against Dengue Hemorrhagic Fever has not been effective as expected.

Objective: Determination of the risk factors of acquiring of severe Dengue hemorrhagic fever in children. Subject and Method: Retrospective study

Result: Through a study of 265 children had Dengue hemorrhagic fever treated at the Department of Tropical Diseases and the Intensive Care Unit of Quang Ngai Obstetrics and Pediatrics Hospital from 6/2020 to 5/2021, we have following results: Dengue without warning signs (51.8%); Dengue with warning signs (47.1%); Severe Dengue (2.6%).

Conclusion: The risk factors of acquiring severe dengue hemorrhagic fever in children are: petechiae, nausea and vomiting, abdominal pain (liver region), hepatomegaly, white blood cell count <5x109/L, Hct≥45%, increase in AST, ALT and signs of plasma leakage on ultrasound.