CLINICAL, SUBCLINICAL FEATURES AND RESULTS OF TREATMENT OF CYTOMEGALOVIRUS HEPATITIS IN CHILDREN
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Abstract
Objective: To describe the clinical and subclinical characteristics of hepatitis in children due to viral cytomegalo-infection and to comment on the results of treatment of hepatitis in children due to viral cytomegalo-infection at the National Children’s Hospital.
Research object and method: Retrospective - prospective study,describing 89 pediatric patients 1-12 months diagnosed with Cytomegalovirus hepatitis and treated at the National Children’s Hospital during the period from 01/01/2020 - 30/06/2022.
Result: 89 patients with CMV hepatitis were followed for 6 months with the following rates: The average age of patients was 2.17 ± 1,596 months, and the ratio of males to females (2.5 : 1), jaundice 86.5%, hepatomegaly 64.0%, feces of silver color 52.8%, dark urine 44.9%, subcutaneous hemorrhage 4.5%. Most transaminases increase slightly and rarely exceed 400U/L. Direct billirubin increased by 91.2%. 66/89 are eligible for antiviral therapy with ganciclovir/ Valganciclovir. Improvement in liver damage was 90.9% and nocomplications accounted for 90.9%.
Conclusion: Most patients have good results after treatment. However, it is necessary to detect and treat in time to limit the severe damage caused by CMV.
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Keywords
hepatitis, Cytomegalovirus
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