RELATION BETWEEN SERUM FERRITIN LEVEL WITH LIVER IRON CONCENTRATION AND CARDIAC T2* MRI IN PATIENTS THALASSEMIA
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Abstract
Thalassemia is an inherited anemia disorders in human. Transfusion-dependent thalassemia is a type of thalassemia characterized by severe anemia and a lifelong dependence on red blood cell transfusions that can lead to iron overload. Optimal iron overload assessment and monitoring is a key element in the development of improved strategies of iron chelation therapy. Objective: Evaluate clinical, paraclinical characterization of iron overload and correlation between serum ferritin, LIC and cardiac T2* in thalassemia at National Children’s Hospital from 2018 to 2020. Methods: Descriptive cross-sectional study. From 8/2018 to 8/2020, A total of 79 patients had both liver and myocardial iron load assessment by MRI. We evaluated the clinical and paraclinical on admission. Result: The mean serum ferritin value was 3298.6 ± 3055.2 ng/ml, LIC was 12.90 ± 5.6 mg/g and cardiac T2* was 29 ±11.7 ms. The correlation between serum ferritin and LIC, cardiac T2* was poor. LIC does not correlate with cardiac T2*.
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Keywords
Iron overload, MRI, thalassemia, children
References
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