NEONATAL INFECTION AND RISK FACTORS IN PREGNANCIES WITH PREMATURE RUPTURE OF MEMBRANES IN TU DU HOSPITAL
Background: Neonatal infection is a common disease in neonates and which is one of the
four leading causes of infant mortality. Objective: To investigate the rate of neonatal infection and risk factors for infections of live infants born in mothers with premature rupture of membranes at Tu Du Hospital. Patients and Method: Review of medical records of live infants born in mothers with premature rupture of membranes diagnosed as neonatal infections and other non-infectious diseases at Tu Du Hospital from January 1, 2020 to June 30, 2020. Results: Among 255 live babies born from mothers with premature rupture of membranes, 24 babies had neonatal infection, accounting for 9.41%. In which, there were mainly pneumonia with 21 children (8.2%) followed by necrotizing enterocolitis with 2 children (0.9%), one child with skin infection (0.4%) and 1 child with umbilical cord infection (0.4%). The most common clinical manifestations in neonatal infection were tachypnea (91.7%) and chest indrawing
(79.2%) followed by asphyxia and vomiting (20.8%). The least common is fever, cyanosis, skin pustules, each sign accounted for only 4.2%. In terms of subclinical examination, leukocytosis was most common with 17(70.8%) infants, then increased CRP, only 4(18.2%) infants and decreased platelets with 3(12.5%) infants and at least 1 (4.2%) infant with positive blood culture. Meanwhile, chest Radiography has lesions up to 21(87.5%) cases and abdominal Radiography with lesions is 2 (8.3%) cases. Risk factors associated with neonatal infection are time to premature rupture of membranes greater than 18 hours, low apgar score of 0-7 points, tachypnea, chest indrawing, vomiting, chest radiography and abdominal radiographs with lesions (p=000 and 0.009).
Conclusion: Neonatal infection is common in neonates whose mothers’ membranes have
broken prematurely. It is necessary to monitor and detect early clinical and subclinical signs at
risk of infection in neonates.
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