MATURE B CELL LYMPHOMA AT VIETNAM NATIONAL CHILDREN’S HOSPITAL: CLINICAL CHARACTERISTICS AND INVESTIGATION FINDINGS
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Tóm tắt
Background: Mature B cell lymphoma (B-NHL) is a highly aggressive and fast-growing human disease in children. Clinical symptoms and investigation fndings have characteristics of lymphoma in general and B NHL in particular, which helps in the diagnosis and treatment process. This study aims to review some clinical characteristics and investigation fndings of B-NHL patients at the Vietnam National Children’s Hospital.
Objective and methods: A descriptive study was carried out in all B-NHL patients under 16 years old that start their treatment in VNCH since 01 January 2015 and end before 30 June 2021, excluding patients can’t follow up.
Results: 84 B-NHL patients had a mean age of 5.4 years. Male accounts for 75%, male/ female ratio is 3/1. The most common clinical symptoms on admission were gastrointestinal symptoms (58.3%), symptoms in the head and neck area appeared less (26.2%). The group had symptoms of onset in the digestive system, the most common was abdominal pain (77.6%), followed by abdominal distension and palpable abdominal mass (42.9%). In the group with symptoms that started in the head and neck region, the most common was the appearance of head and neck mass and cervical lymphadenopathy. Symptoms B was seen in 26 patients (31%). On imaging, 45.2% of patients had tumors from 2 or more locations, 85.7% of patients had lesions in the abdomen, followed by head and neck (40.5%). In the group of abdominal lesions on imaging, the most common are gastrointestinal infltrates and renal infltrates; In the group of lesions in the head, face and neck, sinus and cervical lymph nodes are common. 11.9% of patients had central nervous system (CNS) infltrates and 29.8% of bone marrow infltrates. BL histopathology was the most common (75%), followed by DLBCL 11.9% and others 13.1%. The BL type is more common with bone marrow and CNS metastases than other histopathological types. Patients are mainly in stage 3 (51.2%) and stage 4 (33.3%). 57.1% of patients had LDH concentration below 1000 IU/ml and 45.3% of patients had LDH concentration above 1000 UI/ ml. The c-MYC gene rearrangement was found in 10 out of 15 patients, of which 8 were BL.
Conclusions: Patients with B-NHL had mean age 5.4 years old and their own clinical and investigation characteristics that help in diagnosis, monitoring of treatment.
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Từ khóa
Mature B cell lymphoma, clinical characteristic of mature B cell lymphoma
Tài liệu tham khảo
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